AS 602801

AS 602801 - Names and Identifiers

Name	2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile
Synonyms	CS-401 AS 602801 Bentamapimod Bentamapimod (AS 602801) AS 602801 (BentaMapiMod) Bentamapimod ( AS 602801) (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile 2-(1,3-benzothiazol-2-yl)-2-[2-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]pyrimidin-4-yl]acetonitrile 2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile AS602801(Bentamapimod)
CAS	848344-36-5
EINECS	604-604-1

AS 602801 - Physico-chemical Properties

Molecular Formula	C25H23N5O2S
Molar Mass	457.55
Density	1.326
Boling Point	666.5±65.0 °C(Predicted)
pKa	6.47±0.10(Predicted)
Storage Condition	2-8°C
Use	Bentamapimod, also known as AS602801 and PGL5001, is a JNK Inhibitor. AS602801 induces regression of endometriotic lesions in animal models. AS602801 interrupts immune pathways. Bentamapimod induced regression of endometriotic lesions in endometriosis rodent animal models without suppressing ER action. Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites.
Target	JNK1；JNK2；JNK3

AS 602801 - Reference

Reference

1: Hussein M, Chai DC, Kyama CM, Mwenda JM, Palmer SS, Gotteland JP, D'Hooghe TM.c-Jun NH(2)-terminal kinase inhibitor bentamapimod reduces induced endometriosisin baboons: an assessor-blind placebo-controlled randomized study. Fertil Steril.2015 Dec 2. pii: S0015-0282(15)02106-8. doi: 10.1016/j.fertnstert.2015.11.022.[Epub ahead of print] PubMed PMID: 26654972.
2: Palmer SS, Altan M, Denis D, Tos EG, Gotteland JP, Osteen KG, Bruner-Tran KL,Nataraja SG. Bentamapimod (JNK Inhibitor AS602801) Induces Regression ofEndometriotic Lesions in Animal Models. Reprod Sci. 2016 Jan;23(1):11-23. doi:10.1177/1933719115600553. Epub 2015 Sep 2. PubMed PMID: 26335175.